[Postmortem studies of the brain of suicide victims].
نویسندگان
چکیده
The authors present a bibliography concerning post mortem studies in depression and suicide victims. They stress the difficulties of this trans-disciplinary approach, joining clinical, toxicological, anatomopathological, and biological points of view. Concerning indolamines, catecholamines, receptors studies, an analysis of the results shows major methodological differences. This makes any comparison between these studies impossible. Recommendations are made for an agreement between the groups leading to an uniformity of methodologies.
منابع مشابه
The Expression of the Suicide-Associated Gene SKA2 Is Decreased in the Prefrontal Cortex of Suicide Victims but Not of Nonsuicidal Patients
BACKGROUND Recent study of genome-wide DNA methylation profiling in the postmortem brain of suicidal and nonsuicidal subjects found that gene expression of spindle and kinetochore associated complex subunit 2 (SKA2) is decreased in the postmortem brain of suicide victims compared with nonsuicidal, nonpsychiatric control subjects. METHODS To determine if decreased SKA2 is specific to suicide a...
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Despite the devastating effect of suicide on numerous lives, there is still a lack of knowledge concerning its neurochemical aspects. There is increasing evidence that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in the pathophysiology and treatment of depression through binding and activating their cognate receptors TrkB and TrkA respectively. The present...
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OBJECTIVE Based on the reported association between cytokines with depression and suicide, and evidence of increased markers of inflammation in the brain of suicide victims, the present study examined the expression of cytokines in the orbitofrontal cortex of suicide victims. METHOD In a postmortem sample obtained from the Brodman area 11 of suicides (n = 34) and controls (n = 17), real-time ...
متن کاملPrediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide.
OBJECTIVE Postmortem studies have indicated that suicide victims have greater serotonin receptor 2A (5-HTR2A) binding in prefrontal brain regions. However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized that the variance observed in brain 5-HTR2A binding is genetically mediated, at least in part. METHOD Postmortem data from 56 s...
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Considerable evidence has accrued in the last two decades to support the hypothesis that alterations in serotonergic neuronal function in the central nervous system occur in patients with major depression. These findings include the following: (a) reduced cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of serotonin (5-HT) in drug-free depres...
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عنوان ژورنال:
- L'Encephale
دوره 13 1 شماره
صفحات -
تاریخ انتشار 1987